DNA-repair-deficient Rad54/Rad54B mice are more sensitive to clastogens than wild-type mice
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Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterparts.
It is important to know whether the human population includes genetically predisposed radiosensitive subsets. In vitro studies have shown that cells from individuals homozygous for ataxia telangiectasia (A-T) are much more radiosensitive than cells from unaffected individuals. Although cells heterozygous for the ATM gene (ATM(+/-)) may be slightly more radiosensitive in vitro, it remained to be...
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 2008
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2008.10.005